�UroToday.com - In the September, 2008 issue of the Journal of Urology, Dr. Hiroyoshi Suzuki and Japanese collaborators reported that following utmost androgen seal off (MAB) for prostate crab (CaP), the use of alternative nonsteroidal antiandrogens is effective for treating relapsed disease. A total of 232 CaP patients treated with MAB and disease progression made up the study cohort. Upon disease relapse they were treated with an alternative antiandrogen.
For first-line therapy, 39 men received MAB victimisation flutamide and 193 were treated with MAB using bicalutamide. At the time of CaP progression, the first line antiandrogen was stopped and patients assessed for antiandrogens withdrawal syndrome. Second line antiandrogens were then started. Testosterone was confirmed to be in the emasculate level. Standard disease response criteria were used.
All patients achieved castrate levels of testosterone. Mean patient age was 71.5 years and PSA ahead treatment was 1,047ng/ml. Of the 193 men initially tempered with bicalutamide, 143 (74%) achieved a complete reply (CR) and all attained a CR or partial response (RP). Of the 39 flutamide treated patients, 32 (82%) achieved a CR and all attained a CR or PR. The duration of the first line MAB response was 452 days and cause-specific survival was significantly improved in the CR patients compared to the non-CR manpower. Antiandrogen withdrawal response rates were 15.5% for bicalutamide and 12.8% for flutamide. Second line alternative antiandrogen treatment was effective careless of antiandrogens withdrawal syndrome status.
Second line alternative antiandrogen agents resulted in an overall PSA decrease of 50% or greater in 35.8% and a PSA response of 0 to 50% was noted in 25.4%. There was no remainder with esteem to response between bicalutamide and flutamide. Seventy of the 83 good responders had response duration of 202 days. More than half of the patients that had started mo line therapy at a PSA point
Suzuki H, Okihara K, Miyake H, Fujisawa M, Miyoshi S, Matsumoto T, Fujii M, Takihana Y, Usui T, Matsuda T, Ozono S, Kumon H, Ichikawa T, Miki T
J Urol. 2008 Jul 15. Epub in front of print.
doi:10.1016/j.juro.2008.05.045
Reported by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS
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Yeah Yeah Yeahs
Artist: Yeah Yeah Yeahs
Genre(s):
Pop
Alternative
Indie
Rock
Discography:
Is Is
Year: 2007
Tracks: 5
Show Your Bones
Year: 2006
Tracks: 11
Paredes De Coura
Year: 2006
Tracks: 1
Cheated Hearts (Remix by Peaches)
Year: 2006
Tracks: 3
Tell Me What Rockers To Swallow
Year: 2004
Tracks: 22
Maps CDS
Year: 2003
Tracks: 3
Machine
Year: 2003
Tracks: 3
Fever To Tell
Year: 2003
Tracks: 11
Date With The Night (CDSingle)
Year: 2003
Tracks: 3
Peel Session, 22-Aug-02
Year: 2002
Tracks: 4
Yeah Yeah Yeahs EP
Year: 2001
Tracks: 5
Fates Of Life
Year:
Tracks: 11
Discovered in the wake of the Strokes' popularity and the subsequent service department sway revitalisation meeting, New York's art punk tercet the Yeah Yeah Yeahs are comprised of singer Karen O, guitarist Nicolas Zinner, and drummer Brian Chase. O met Chase at Ohio's Oberlin College and met Zinner through friends later she transferred to NYU. Zinner and O formed the ring in 2000; originally, they were a folky duette called Unitard, merely they went galvanising after being divine by Ohio's fabled avant hood scene. After the drummer they recruited initially bowed out, Chase joined the batting order of magnitude.
The Yeah Yeah Yeahs wrote a curve of songs at their first rehearsal and presently wounding up supporting the Strokes and the White Stripes, earning a significant hum for their arty til now aphrodisiac accept on service department tinder. In late 2001, the Yeah Yeah Yeahs released their self-titled debut EP, which they recorded with Boss Hog's Jerry Teel, on their have Shifty label. Early the next year the stria stepped into the international spot, appearance at South by Southwest, touring the U.S. with Girls Against Boys and Europe with Jon Spencer Blues Explosion, and headlining their have U.K. duty tour. Wichita Recordings distributed the group's EP in the U.K. and Touch and Go reissued it in the States.
In between tours, the group worn-out 2002 putting the coating touches on its uncut debut and playing American dates with Sleater-Kinney, Liars, and Jon Spencer Blues Explosion. Late that year, the Yeah Yeah Yeahs released the Machine EP to tide fans over before their number one uncut. The Yeah Yeah Yeahs stirred to Interscope for their debut album, 2003's Fever to Tell. Boasting a cleaner sound and more eclectic songwriting than their EPs, the album continued their critical spat and besides won them a fair amount of commercial achiever: the gorgeous lay "Maps" became a attain in 2004 and pushed Febrility to Tell to gold status that year. Karen O besides moved to Los Angeles in 2004, making the Yeah Yeah Yeahs a bicoastal band.
The group took some time to pursue single projects in 2005. O loaned her vocals to "Hello Tomorrow," a collaboration with manufacturer Squeak E. Clean that provided the soundtrack to a Nike horseshoe commercial directed by Spike Jonze, spell Zinner recorded with the side project Head Wound City and besides had a book of photographs, I Hope You Are All Happy Now, published. The Yeah Yeah Yeahs reconvened in the studio that year to record their second album with Clean as producer; jokingly, Clean aforementioned that the album was most O's big cat and would be called Coconut tree Beware, merely the album's substantial form of address, Show Your Bones, was revealed presently subsequently. Released in spring 2006, the album was the band's most mature, polished work in time, and reached number 11 on the record album charts. The Yeah Yeah Yeahs worn-out the rest of the year touring in supporting of the album, and returned in summer 2007 with the Is Is EP, a collection of new recorded versions of songs written in 'tween the band's deuce albums.
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